1,25 Di Hydroxy Vitamin D
Also Known As
Test Parameters Included
- Serum 1,25-dihydroxyvitamin D Concentration (pg/mL) - active vitamin D metabolite
- Pathologist Clinical Biochemistry Remark - interpreted alongside calcium, phosphorus, and PTH levels
Department
Methodology
Sample Required
Preparation
Schedule Report
24 Hours
Emergency Report
Yes
Frequently Asked Questions
Why is 1,25-dihydroxyvitamin D different from vitamin D3 supplement?
Vitamin D3 (cholecalciferol) is the precursor, while 1,25-dihydroxyvitamin D is the active hormonal form produced by kidneys. Supplementation raises 25-OH vitamin D, not necessarily 1,25-OH2D.
Who needs this test instead of 25-OH vitamin D?
Patients with kidney disease, hyperparathyroidism, or granulomatous disorders like sarcoidosis. Kidney impairment reduces conversion to active form despite adequate vitamin D stores.
Does fasting affect 1,25-dihydroxyvitamin D levels?
No, fasting is not required. This hormone is stable and can be measured at any time of day.
What causes low 1,25-dihydroxyvitamin D?
Chronic kidney disease is the most common cause, as damaged kidneys cannot hydroxylate vitamin D to its active form. Vitamin D deficiency and hypoparathyroidism also lower levels.
Can high 1,25-dihydroxyvitamin D be dangerous?
Yes, elevated levels cause hypercalcemia, leading to nausea, confusion, kidney stones, and vascular calcification. Granulomatous diseases and lymphomas can overproduce active vitamin D.
Test Description
Test Code
D01
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