MTB/XDR Detection PCR
Also Known As
Test Parameters Included
- Mycobacterium tuberculosis complex DNA detection with simultaneous rifampicin and isoniazid resistance mutation profiling (qualitative)
- Pathologist Molecular Microbiology Remark - correlated with clinical presentation and drug-resistance pattern interpretation
Department
Methodology
Sample Required
Preparation
Schedule Report
5 Days
Emergency Report
Yes
Frequently Asked Questions
What does MTB/XDR Detection PCR test for?
This molecular test detects Mycobacterium tuberculosis complex DNA and simultaneously identifies genetic mutations responsible for resistance to rifampicin and isoniazid, the two most important first-line anti-TB drugs.
What sample is required for this test?
The test can be performed on sputum, pleural fluid, CSF, tissue samples, or other body fluids. Adequate sample volume is essential for accurate nucleic acid extraction and detection.
How is the HAINS Line Probe Assay different from routine PCR?
The HAINS (Hybridization Assay) Line Probe Assay uses reverse hybridization with specific probes to detect MTB DNA and point mutations in rpoB and katG/inhA genes, providing rapid resistance profiling within 1-2 days.
What does XDR-TB mean in this test?
XDR-TB stands for Extensively Drug-Resistant Tuberculosis, meaning the MTB strain is resistant to rifampicin, isoniazid, and at least one fluoroquinolone and one injectable second-line drug. This test identifies key resistance mutations to guide appropriate treatment.
Is fasting required for this test?
No, fasting is not required for MTB/XDR Detection PCR. Sample collection depends on the source (sputum induction, fluid aspiration) rather than dietary restrictions.
How quickly are results available?
Results are typically available within 24-48 hours. Early detection of drug resistance helps clinicians initiate appropriate second-line therapy promptly, improving patient outcomes.
Test Description
Test Code
T48
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