MTB DNA PCR (TISSUE)
Also Known As
Test Parameters Included
- Mycobacterium tuberculosis DNA Detection (Qualitative) - PCR amplification of MTB-specific gene targets (IS6110 / MPB64)
- Pathologist Molecular Biology Remark - positive result indicates presence of MTB DNA in tissue, correlates with active or prior mycobacterial infection
Department
Methodology
Sample Required
Preparation
Schedule Report
24 hours
Emergency Report
Yes
Frequently Asked Questions
What does MTB DNA PCR on tissue detect?
It detects Mycobacterium tuberculosis-specific DNA sequences (such as IS6110 and MPB64 regions) in tissue biopsy samples, helping confirm TB infection in extrapulmonary sites like lymph nodes, bone, or pleura.
Is fasting required for this test?
No, fasting is not required. This is a molecular test performed on tissue samples, not a blood metabolic test.
What type of sample is needed?
A tissue sample of approximately 5 grams, preferably preserved in sterile container or formalin-fixed paraffin-embedded (FFPE) block, collected via biopsy or surgical excision.
How long does it take to get results?
Results are typically available within 24–48 hours from sample receipt at Dr. Patho Labs, Chhatrapati Sambhajinagar.
Can a negative PCR result rule out TB?
A negative result reduces the likelihood of active TB but does not completely exclude it, as low bacterial load or PCR inhibitors in the tissue may cause false negatives. Clinical correlation and culture remain important.
How is the result interpreted?
A positive result confirms MTB DNA in the tissue and supports a diagnosis of tuberculosis. The pathologist correlates findings with clinical presentation, histopathology, and other investigations for definitive diagnosis.
Test Description
Test Code
M19
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