Liver Kidney Microsome LKM1 Antibody
Also Known As
Test Parameters Included
- LKM1 Antibody Titer (Positive/Negative at reporting dilution) - semi-quantitative immunofluorescence or ELISA titer
- Pathologist Immunology Remark - correlated with autoimmune hepatitis type 2 and drug-induced autoimmunity reference intervals
Department
Methodology
Sample Required
Preparation
Schedule Report
24 Hours
Emergency Report
Yes
Frequently Asked Questions
What does the LKM1 antibody test measure?
It detects autoantibodies directed against liver kidney microsome type 1 antigen (CYP2D6 enzyme), which is found in liver and kidney tissues. These antibodies are a key serological marker for autoimmune hepatitis type 2.
Is fasting required for this test?
No, fasting is not required for LKM1 antibody testing. The sample can be collected at any time of day without dietary restrictions.
What does a positive LKM1 antibody result indicate?
A positive result is strongly associated with autoimmune hepatitis type 2, which predominantly affects children and young adults. It may also be seen in autoimmune hepatitis type 3, primary biliary cholangitis, and certain drug-induced autoimmune conditions.
How are LKM1 antibody results reported?
Results are typically reported as positive or negative along with the antibody titer (e.g., 1:40, 1:160, 1:640). Higher titers generally correlate with greater disease activity and are more specific for autoimmune hepatitis type 2.
How is LKM1 different from ANA and SMA tests?
LKM1 targets the CYP2D6 enzyme in liver and kidney microsomes, while ANA targets nuclear components and SMA targets smooth muscle actin. Autoimmune hepatitis type 2 is LKM1-positive but ANA/SMA-negative, helping differentiate it from type 1 AIH.
How to access the report?
Verified PDF report is available within 24-48 hours via www.drpatholab.in or WhatsApp/Email after sample collection.
Test Description
Test Code
L21
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