Test

HOMA IR Insulin Resistance (3 Parameters)

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Also Known As

#1) Insulin Sensitivity Score #2) HOMA-IR Index #3) Metabolic Health Screen #4) Insulin Resistance Audit #5) HOMA-Index Profile #6) Pre-Diabetes Insulin Check #7) HOMA Score (Glucose & Insulin) #8) Pancreatic Beta-Cell Function Test #9) Insulin Resistance Baseline #10) HOMA1-IR #11) Glycemic Control Assessment #12) Hyperinsulinemia Screen #13) Metabolic Syndrome Marker #14) Fasting Insulin/Glucose Ratio #15) Early Metabolic Dysfunction Test
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Test Parameters Included

  • Fasting Glucose (Method: Hexokinase): The amount of sugar currently in your bloodstream after an 8-12 hour fast. We use the Hexokinase method, the reference standard for accuracy.
  • Fasting Insulin (Method: ECLIA): Measures the amount of insulin your pancreas is secreting while you are at rest. Using ECLIA (Electrochemiluminescence) ensures we can detect even very small amounts of this hormone.
  • HOMA-IR (Method: Calculated): This is a mathematical calculation using the formula, This result tells us if your insulin and glucose are in "harmony" or if your body is struggling.
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Department

CLINICAL BIOCHEMISTRY

Methodology

Chemiluminescence(Calculated): This profile combines the high-precision Hexokinase enzymatic method for glucose with ECLIA (Electrochemiluminescence Immunoassay) for insulin. The HOMA-IR is then electronically calculated to provide a standardized index of your metabolic efficiency.
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Sample Required

SERUM (1ML), Na Fluoride Fasting (2ML)

Preparation

* Strict Fasting: You must fast for 8 to 12 hours. An overnight fast is ideal. * Allowed: Only plain water is permitted. * Avoid: No tea, coffee, smoking, or exercise on the morning of the test, as these can spike insulin levels. * Medication: Inform your doctor if you are taking Metformin, Insulin, or any steroids, as these will significantly alter the calculation. * Biotin Alert: Stop high-dose Biotin supplements 72 hours prior, as it interferes with the Insulin ECLIA method.
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Schedule Report

24 Hours

Emergency Report

Yes

Frequently Asked Questions

Why not just check sugar?

You can have "normal" sugar but "high" insulin. This means your body is working 10 times harder than it should to keep sugar normal. HOMA-IR catches this "struggle."

Why does the report take 24 hours?

While the glucose is fast, the Insulin ECLIA requires specific batching and careful calibration to ensure the calculation is 100% accurate.

Can I drink black coffee while fasting?

No. Caffeine can trigger a release of stored sugar from the liver, which causes insulin to rise, ruining the HOMA-IR calculation.

Is a HOMA-IR of 2.5 bad?

It indicates moderate insulin resistance. It is a "wake-up call" to adjust diet and exercise before it progresses to diabetes.

Can exercise improve my score?

Absolutely! Muscle movement is the best way to make your cells more sensitive to insulin.

Why is my insulin high if my sugar is normal?

This is "Hyperinsulinemia." Your pancreas is overcompensating to keep you healthy, but it can't do this forever.

What is the "405" in the formula?

It is a constant used to standardize the units (mg/dL and \mu U/mL) for the calculation.

Can I take this test while pregnant?

Yes, but HOMA-IR ranges are different during pregnancy. Consult your OB-GYN.

Does stress affect HOMA-IR?

Yes. Cortisol (stress hormone) raises sugar and insulin, which will inflate your HOMA-IR score.

Can I take Metformin before the test?

No, unless specifically told by your doctor. Metformin lowers insulin resistance and will mask your "natural" baseline.

Why is the Hexokinase method used?

It is the most accurate way to measure glucose without interference from other substances in your blood.

Is HOMA-IR used for PCOS?

Yes, it is a primary tool to help determine if a patient's PCOS is driven by insulin issues.

Why must I rest before the draw?

Any physical exertion can change your blood sugar and insulin dynamics.

Does smoking affect the result?

Yes. Nicotine increases insulin resistance temporarily. Avoid smoking for 12 hours before.

Is the test result confidential?

Yes. At Dr. Patho, all metabolic health data is protected by strict privacy protocols.

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Test Description

HOMA IR Insulin Resistance (3 Parameters) Examination Overview The HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) is a sophisticated d... Read more

Test Code

H81

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