Hepatitis ABCE Screening Comprehensive Panel (10 Tests) - Quantitative ELISA
Also Known As
Test Parameters Included
- Hepatitis E Virus - IgM (HEV IgM) ELISA: Detects recent or acute Hepatitis E infection.
- Hepatitis A Virus - IgM (HAV-IgM) ELISA: Indicates acute or recent Hepatitis A infection.
- Hepatitis A Virus - Total (HAV Total) ELISA: Detects both acute and past Hepatitis A infection, as well as immunity from vaccination or prior exposure.
- Hepatitis B Core Antibody IgM (Anti HBc - IgM) ELISA: A key marker for acute Hepatitis B infection or a recent flare-up of chronic infection.
- Hepatitis B Core Antibody Total (HBcAb- Total) ELISA: Indicates past or current Hepatitis B infection (does not distinguish between acute and chronic). It appears shortly after HBsAg and persists for life.
- Hepatitis C Virus (HCV Antibody) ELISA: Screens for exposure to Hepatitis C virus. A positive result usually indicates chronic infection and requires confirmatory testing (e.g., HCV RNA PCR).
- Hepatitis B Surface Antibody Total (Anti HBs) ELISA: Indicates immunity to Hepatitis B, either from successful vaccination or recovery from a past infection.
- Hepatitis B Surface Antigen (HBsAg) ELISA: The primary marker for active Hepatitis B infection (acute or chronic). Its presence means the virus is currently in the body.
- Hepatitis B Envelope Antibody (AntiHBe) ELISA: Indicates seroconversion from HBeAg, often correlating with reduced viral replication and lower infectivity.
- Hepatitis B Envelope Antigen (HBeAg) ELISA: Indicates active viral replication and high infectivity of Hepatitis B.
Department
Methodology
ELISA (Enzyme-Linked Immunosorbent Assay) is a highly sensitive and specific immunoassay widely used for the quantitative detection of antibodies and antigens in blood samples. In this comprehensive panel, ELISA is employed for each parameter to precisely measure the concentration of various hepatitis virus markers. The technique involves a series of steps where specific antibodies or antigens are immobilized on a solid surface. When the patient's sample is added, any target (virus antigen or antibody) present binds to the immobilized components. Subsequent steps involve adding enzyme-linked antibodies that react to produce a colored product, the intensity of which is quantitatively measured by a spectrophotometer. This quantitative measurement allows for precise determination of antibody or antigen levels, providing a detailed picture of the infection status, stage, and immune response.
Sample Required
Preparation
* No Fasting Required: Fasting is not necessary for this blood test.
* No Special Timing: Blood can be drawn at any time of day.
* Inform Clinician: Disclose any recent symptoms, known exposures, vaccination history (especially for Hepatitis A or B), and any existing liver conditions to your healthcare provider for accurate interpretation of results.
Schedule Report
24-48 Hours
Emergency Report
Yes
Frequently Asked Questions
What is the main benefit of this Comprehensive Hepatitis Panel?
It provides a detailed, quantitative assessment of your status for Hepatitis A, B, C, and E, including current infection, past exposure, and immunity, helping in accurate diagnosis and management.
What methodology is used for all tests in this panel?
All parameters in this comprehensive panel are analyzed quantitatively using the ELISA (Enzyme-Linked Immunosorbent Assay) methodology.
What type of sample is required?
A blood sample is required, from which serum will be separated for analysis.
How quickly will I receive my results?
The report will be available within 24 hours.
Is fasting or any special preparation needed for this test?
No, fasting is not required, and there are no other special preparations needed for this blood test.
Why are there so many markers for Hepatitis B in the panel?
Hepatitis B has several markers (HBsAg, Anti-HBs, HBeAg, Anti-HBe, Anti-HBc IgM, Anti-HBc Total) that appear and disappear at different stages of infection, helping to distinguish between acute, chronic, resolved infection, and immunity due to vaccination.
What does a positive HCV Antibody test mean?
A positive HCV Antibody usually indicates exposure to Hepatitis C virus. It typically means you have or had an HCV infection. A confirmatory HCV RNA PCR test is needed to determine if there's an active infection.
Can this test tell me if I am immune to Hepatitis A or B?
Yes. A positive HAV Total (in the absence of acute IgM) suggests past infection or immunity from vaccination for Hepatitis A. A positive Anti HBs indicates immunity to Hepatitis B, usually from vaccination or successful recovery from infection.
What should I do if my results are positive for any hepatitis marker?
If any marker is positive, it's crucial to consult with your healthcare provider immediately. They will interpret the results in your clinical context and advise on further confirmatory tests, treatment, or management strategies.
Is this test suitable for individuals recently exposed to hepatitis?
Yes, it includes IgM markers for HAV and HEV, and core IgM for HBV, which are important for detecting recent or acute infections. However, the timing of testing relative to exposure is crucial.
Test Description
Test Code
PH6
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