H. Pylori - Helicobacter Pylori PCR - Tissue / Blood / Stool
Also Known As
* Helicobacter pylori Molecular Detection
* H. pylori Nucleic Acid Test
* Gastric Biopsy H. pylori PCR
* Stool H. pylori DNA Test
* H. pylori Resistance PCR
* H. pylori PCR Multi-Sample
* Helicobacter pylori Genetic Test
* H. pylori Detection by PCR
* PCR for Gastric Ulcer Bacteria
Test Parameters Included
- Helicobacter pylori DNA Detection (qualitative) - PCR-based identification of H. pylori genetic material from tissue biopsy, blood, or stool specimen
- Pathologist Molecular Biology Remark - correlated with clinical presentation and endoscopic findings for diagnosis of H. pylori-associated gastritis, peptic ulcer disease, or gastric malignancy risk
Department
Methodology
Sample Required
Preparation
* For Stool Sample:
* No Antibiotics: Do NOT take antibiotics or bismuth-containing medications (e.g., Pepto-Bismol) for at least 4 weeks prior to the test, as these can suppress H. pylori and lead to false-negative results.
* No Proton Pump Inhibitors (PPIs): Avoid PPIs (e.g., omeprazole, pantoprazole) for at least 1-2 weeks before the test, as they can also suppress the bacteria. Consult your doctor before stopping any medication.
* Sample Collection: Collect the stool sample in a sterile, clean, dry container provided by the laboratory. Follow instructions precisely to avoid contamination and ensure sufficient sample quantity.
* Storage and Transport: Keep the sample refrigerated and transport it to the lab as soon as possible.
2. For Tissue Biopsy (Endoscopy):
* Fasting: You will need to fast for 6-8 hours (no food or drink) before the endoscopy procedure.
* Medication Review: Inform your doctor about all medications, especially blood thinners or antacids/PPIs. PPIs and antibiotics should generally be stopped for at least 1-2 weeks and 4 weeks, respectively, before the biopsy for optimal H. pylori detection. Your doctor will advise on stopping medications.
* Procedure: The biopsy will be collected by a gastroenterologist during an upper endoscopy.
3. For Blood Sample:
* No Fasting Required: Fasting is generally not required for a blood sample for H. pylori PCR.
* Medication Disclosure: Inform your doctor about any medications you are taking, though they are less likely to directly impact blood PCR compared to stool/tissue.
* Sample Collection: A standard blood draw will be performed into an EDTA tube.
Schedule Report
72 hours
Emergency Report
Yes
Frequently Asked Questions
What does the Helicobacter Pylori PCR test detect?
This test directly detects the genetic material (DNA) of Helicobacter pylori bacteria in various samples, confirming an active infection.
What sample types can be used for this PCR test?
The test can be performed on tissue biopsy samples (from endoscopy), stool samples, or blood samples.
How is PCR different from other H. pylori tests like antibody or breath tests?
PCR directly detects the bacterial DNA, confirming active infection, and can also identify antibiotic resistance genes. Antibody tests only show exposure, and breath/stool antigen tests indicate active infection but don't provide genetic information.
Is fasting required for the H. pylori PCR test?
Fasting is required only if a tissue biopsy is being taken (for endoscopy). For stool or blood samples, fasting is generally not needed.
What medications should I avoid before the test?
For stool or tissue PCR, you should avoid antibiotics for at least 4 weeks and Proton Pump Inhibitors (PPIs) for 1-2 weeks prior to testing, as they can lead to false negative results. Always consult your doctor before stopping any medication.
How quickly will I get the results for this PCR test?
The report turnaround time for the Helicobacter Pylori PCR test is 72 hours.
Can this test identify antibiotic resistance?
Yes, PCR on tissue samples can be adapted to detect specific gene mutations (e.g., 23S rRNA gene mutations for clarithromycin resistance), which helps in choosing the most effective antibiotic treatment.
When is stool PCR preferred over tissue PCR?
Stool PCR is a non-invasive option, often preferred for initial diagnosis or to confirm eradication after treatment, especially when endoscopy is not required for other reasons.
If my H. pylori PCR is positive, what does it mean?
A positive result confirms an active H. pylori infection. Your doctor will then recommend appropriate antibiotic eradication therapy, potentially guided by resistance patterns if tested.
Can this test be used to check if treatment was successful?
Yes, stool PCR is commonly used 4-6 weeks after completing eradication therapy to confirm that the H. pylori infection has been successfully cleared.
Test Description
Test Code
H07
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