Flow Cytometry - CD117 ( Myeloid Cell Marker ) *
Also Known As
Test Parameters Included
- CD117 (c-KIT) Fluorescence Expression on Myeloid Cell Populations - reported as percentage of positive cells and mean fluorescence intensity
- Pathologist Hematopathology Remark - correlated with immunophenotypic reference for myeloid and mast cell disorders
Department
Methodology
Sample Required
Preparation
Schedule Report
24-48 Hours
Emergency Report
Yes
Frequently Asked Questions
What does CD117 (c-KIT) flow cytometry detect?
CD117 is a transmembrane receptor tyrosine kinase expressed on myeloid progenitor cells, mast cells, and hematopoietic stem cells. Flow cytometry quantifies its expression to aid in diagnosing myeloid malignancies and mast cell disorders.
Why is CD117 important in blood disorders?
Aberrant or increased CD117 expression is seen in acute myeloid leukemia (AML), chronic myeloid leukemia (CML), systemic mastocytosis, and myelodysplastic syndromes. It serves as both a diagnostic and therapeutic target marker.
Is fasting required for this test?
No, fasting is not required for CD117 flow cytometry. The test can be performed at any time during lab working hours.
What sample is collected for CD117 testing?
EDTA whole blood or bone marrow aspirate is collected. The sample is processed promptly to preserve cell surface antigen integrity for accurate flow cytometric analysis.
How long does it take to get results?
Results are typically available within 24–48 hours. A certified pathologist reviews the immunophenotypic profile before report release.
Can medications affect CD117 flow cytometry results?
Certain tyrosine kinase inhibitors (e.g., imatinib) used in CML or GIST treatment may alter CD117 expression levels. Always inform your doctor about current medications before testing.
Test Description
Test Code
FCM06
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