ANA Blot / ENA Profile - Quantitative
Also Known As
Test Parameters Included
- The profile typically quantifies antibodies against specific antigens, including:
- n-RNP/Sm: Primary marker for Mixed Connective Tissue Disease (MCTD).
- Sm (Smith): Highly specific for Systemic Lupus Erythematosus (SLE).
- SS-A (Ro) & SS-B (La): Markers for Sjögren's Syndrome and Neonatal Lupus.
- Scl-70: Associated with Diffuse Systemic Sclerosis (Scleroderma).
- Jo-1: Indicator for Polymyositis or Dermatomyositis.
- CENP B: Marker for CREST syndrome.
Department
Methodology
Sample Required
Preparation
Schedule Report
24 Hours
Emergency Report
Yes
Frequently Asked Questions
Why do I need an ENA if my ANA was positive?
ANA only says "something" is wrong; ENA identifies "exactly what" is wrong so your doctor can start the right treatment.
Why does the report take 24 hours?
Immunoblotting is a multi-step procedure involving long incubation periods to ensure antibodies bind correctly to the antigens.
Does a positive result mean I have Lupus?
Not necessarily. While Sm is specific for Lupus, other markers like SS-A or Jo-1 point toward different conditions.
Can a healthy person have a positive ENA?
It is rare, but some people carry low levels of these antibodies without having a full-blown autoimmune disease.
What does "Quantitative" mean?
It means we don't just say "Yes" or "No"; we provide a numerical intensity value to show how strong the immune reaction is.
Can I take this test if I'm pregnant?
Yes, and it is specifically used to check for SS-A/SS-B antibodies that can affect the baby's heart.
What is "Sjögren's Syndrome"?
An autoimmune disorder that mainly attacks moisture-producing glands, causing very dry eyes and mouth.
Can stress cause a positive ENA?
No, these are specific genetic and immune markers. Stress can trigger a "flare-up" of symptoms, but it won't create these antibodies from scratch.
Why is Immunoblot better than other methods?
It allows us to test for many different antibodies simultaneously from a single blood sample with very high accuracy.
Can I drink water before the test?
Yes, staying hydrated is fine and makes the blood draw easier.
What is "MCTD"?
Mixed Connective Tissue Disease is a condition that has overlapping features of Lupus, Scleroderma, and Polymyositis.
Does a "Negative" result rule out everything?
It rules out common nuclear antibodies, but your doctor may still investigate other causes if your symptoms are severe.
Is this test done on children?
Yes, it is used to diagnose juvenile autoimmune conditions.
What if my result is "Borderline"?
This often means the immune response is just starting or is very mild; your doctor will likely repeat the test in a few months.
Is the test result confidential?
Absolutely. At Dr. Patho Labs & Diagnostics, your autoimmune data is protected by the highest level of privacy.
Test Description
Test Code
E26
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