Cytogenetic Analysis - Inv 3 (MECOM Break Apart)
Also Known As
Test Parameters Included
- MECOM (MDS1 and EVI1 complex locus) gene rearrangement status - inversion 3 detected via FISH break-apart probe
- Pathologist Cytogenetics Remark - correlated with myeloid neoplasm reference intervals
Department
Methodology
Sample Required
Preparation
Schedule Report
3 DAYS
Emergency Report
Yes
Frequently Asked Questions
What does the MECOM Break Apart test detect?
It detects inversion 3 inv(3)(q21q26.2) and translocations involving the MECOM gene locus, which are associated with myelodysplastic syndromes and acute myeloid leukemia.
What sample is required for this test?
Whole blood in heparin or bone marrow aspirate in heparin is collected for FISH-based cytogenetic analysis.
Is fasting required before this test?
No, fasting is not required for cytogenetic analysis. Sample collection can proceed without dietary restrictions.
How long does the report take?
Cytogenetic analysis typically requires 7-14 days for culture and FISH processing. Reports are available via www.drpatholab.in.
What is the clinical significance of inv(3)?
Inversion 3 is a recurrent abnormality in MDS and AML, often associated with thrombocytosis, dysmegakaryopoiesis, and altered prognosis. It is classified as an adverse risk marker in myeloid neoplasms.
Can this test be done on peripheral blood?
Yes, both whole blood and bone marrow aspirate samples are accepted. Bone marrow is preferred for higher yield in cytogenetic evaluation.
Test Description
Test Code
CYG88
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