CD5 IHC MARKER
Also Known As
Test Parameters Included
- CD5 Protein Expression (positive/negative) by immunohistochemical staining on tissue section
- Pathologist Histopathology Remark - correlated with lymphoid neoplasm differential diagnosis
Department
Methodology
Sample Required
Preparation
Schedule Report
5 Days
Emergency Report
Yes
Frequently Asked Questions
What is CD5 IHC used for in pathology?
CD5 immunohistochemistry is used to identify T-cell lineage and certain B-cell neoplasms such as chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and mantle cell lymphoma, aiding in lymphoma subtyping.
What sample is required for CD5 IHC?
The sample is a tissue specimen submitted in saline with antibiotics, typically a biopsy or surgical resection, processed as an FFPE block for immunohistochemical staining.
Why is CD5 important in diagnosing lymphoma?
Most B-cell lymphomas are CD5-negative. CD5 positivity in a B-cell lymphoma raises suspicion for CLL/SLL or mantle cell lymphoma, which significantly changes treatment and prognosis.
How long does the CD5 IHC report take?
CD5 IHC is typically added as a supplementary stain after initial H&E evaluation. Reports are generally available within 24–48 hours after the base histopathology report via www.drpatholab.in or WhatsApp/Email.
Is fasting required before CD5 IHC testing?
No, fasting is not required. CD5 IHC is performed on tissue biopsy samples, not blood, and does not depend on fasting status.
Can CD5 staining results be inconclusive?
Yes, weak or partial CD5 expression may require additional markers (such as CD23, cyclin D1, or BCL2) to differentiate between CLL/SLL and mantle cell lymphoma, which both express CD5.
Test Description
Test Code
PC127
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