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Appropriate Type 2 Diabetes Profile (8 Parameters)

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Also Known As

#1) Comprehensive Metabolic Insulin Profile #2) HOMA-IR & Beta Cell Assessment #3) Advanced Type 2 Diagnostic Panel #4) Pancreatic Reserve & Resistance Screen #5) C-Peptide and Insulin Sensitivity Profile #6) Diabetes Pathophysiology Screen #7) Insulin Resistance (IR) Audit #8) Complete Glycemic Health Panel #9) Diabetes Management Advanced Screen #10) Beta Cell Functionality Test #11) Hyperinsulinemia Evaluation #12) Type 2 Diabetes Characterization Panel #13) Metabolic Syndrome & IR Profile #14) Post-Prandial Insulin Response Test #15) Functional Diabetic Baseline
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Test Parameters Included

  • Serum Insulin Fasting
  • C-Peptide
  • HOMA-IR - Insulin Resistance
  • Insulin Sensitivity
  • Beta cell function
  • Glycosylated Hemoglobin (GHb/HbA1c)
  • Glucose - Fasting
  • Glucose - Post Prandial

PARAMETERS EXPLAINED:

1. HOMA-IR 2 (Insulin Resistance, Sensitivity & Beta Cell Function): This is a mathematical model derived from Fasting Insulin and Fasting Glucose. It provides three critical insights: Insulin Resistance: How much your cells are "ignoring" insulin. Insulin Sensitivity: How effectively your body uses insulin. Beta Cell Function (%B): The health and productivity of the insulin-producing cells in your pancreas.

2. C-Peptide: C-Peptide is produced in equal amounts to insulin but stays in the blood longer. It is the best marker for measuring your body's natural insulin production, as it is not affected by injected insulin. This helps determine if your pancreas is still making enough insulin.

3. Serum Insulin - Fasting: Measures the amount of insulin circulating while the body is at rest. High levels often indicate that the body is overcompensating for insulin resistance.

4. Glycosylated Hemoglobin (HbA1c) with HPLC: Provides a 3-month average of blood sugar levels. We use the HPLC Gold Standard to ensure the highest accuracy, unaffected by most blood variations.

5. Glucose - Fasting (FBS) & Post Prandial (PPBS): The standard baseline and peak glucose measurements used to evaluate immediate sugar handling after 8 hours of rest and 2 hours after a meal.

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Department

CLINICAL BIOCHEMISTRY

Methodology

HPLC: For gold-standard HbA1c accuracy. Hexokinase: For high-precision glucose measurement. Chemiluminescence (CLIA): For ultra-sensitive Insulin and C-Peptide detection.
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Sample Required

EDTA, Serum, Na Fluoride Fasting, Na Fluoride PP

Preparation

* Strict Fasting: An 8–12 hour overnight fast is mandatory for Fasting Glucose, Insulin, and C-Peptide. * The Second Draw: After the fasting sample, consume a standard meal. The Post Prandial (PP) sample must be drawn exactly 2 hours after the start of the meal. * Avoid Medications: Discuss with your doctor whether to delay your morning diabetes medication until after the fasting draw. * Biotin Alert: Stop Biotin supplements for 72 hours prior, as it interferes with the Chemiluminescence methodology.
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Schedule Report

10 Hours

Emergency Report

Yes

Frequently Asked Questions

What is HOMA-IR?

It stands for Homeostatic Model Assessment for Insulin Resistance. It tells us the "pressure" your pancreas is under to maintain blood sugar.

Why check C-Peptide?

It is the most accurate way to see how much insulin your body is making, especially if you are already taking insulin injections.

Can I have normal sugar and still be "Diabetic"?

You can have normal sugar but very high insulin. This is called "Insulin Resistance" and is the stage just before diabetes.

Why do I need to test at 2 hours for PP?

This is the window when sugar should be returning to normal. If it's still high, the pancreas or cells are struggling.

Does stress affect HOMA-IR?

Yes. Stress increases cortisol, which naturally increases insulin resistance.

What is Beta Cell Function?

Beta cells are the "factory" in the pancreas. This test tells us if the factory is running at 100% or if it's starting to fail.

Why is HPLC used for HbA1c?

It is the most precise method available, ensuring that your 3-month average is not skewed by other factors in your blood.

Can I drink water while fasting?

Yes, plain water is fine.

What does "Insulin Sensitivity" mean?

It is the opposite of resistance. It tells us how "sensitive" or responsive your cells are to insulin. High sensitivity is good.

How can I improve my HOMA-IR score?

Weight loss, strength training, and a low-carbohydrate diet are the most effective ways to lower insulin resistance.

Why is the C-Peptide draw done while fasting?

A fasting state provides a clean baseline of your pancreas's "idling" production.

Does Metformin affect these results?

Yes, Metformin improves insulin sensitivity, so your HOMA-IR score may look better while on the medication.

Is this test useful for PCOS?

Yes, insulin resistance is a core feature of PCOS, and this profile helps manage the condition.

What is the "Post Examination Review"?

A medical professional reviews these complex mathematical models to provide a clear summary of your metabolic health.

Why does the report take 24 hours?

Calculating the HOMA-IR 2 model and running high-sensitivity Chemiluminescence requires careful calibration and data validation.

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Test Description

Appropriate Type 2 Diabetes Profile (8 Parameters) Examination The Appropriate Type 2 Diabetes Profile is a sophisticated diagnostic suite designed t... Read more

Test Code

C52,Ho81,G09,G04,G05

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