New Born Screening NBS - TMS 52 Conditions - TMS
Test Code
MOG44
Also Known As
No data available
Test Parameters Included
No data available
Department
MOLECULAR GENETICS
Methodology
TMS (Tandem Mass Spectrometry)
The primary and sole methodology for this specific newborn screening panel is Tandem Mass Spectrometry (TMS). TMS is a highly sensitive and specific analytical technique used to rapidly measure the concentrations of various metabolites (e.g., amino acids, acylcarnitines, succinylacetones) from a small volume of dried blood spot (DBS). This technology allows for the simultaneous screening of a large number of diverse metabolic disorders within a single test run.
The principle of TMS for newborn screening involves:
* Sample Preparation: A small punch from the dried blood spot card is taken.
* Extraction: Metabolites are extracted from the blood spot.
* Derivatization (Optional): Some metabolites may undergo chemical modification to enhance detection.
* Mass Spectrometry Analysis: The extracted metabolites are ionized and then passed through two mass analyzers in tandem. The first analyzer separates ions by mass-to-charge ratio, and the second performs fragmentation of selected ions, creating a unique "fingerprint" for each metabolite.
* Quantification and Comparison: The quantity of each metabolite is measured and compared to established reference ranges. Abnormal levels or ratios of specific metabolites are indicative of particular metabolic disorders.
TMS is highly efficient, requires a minimal sample volume, and is automated, making it ideal for high-throughput newborn screening programs.
Sample Required
Dried Blood Spot (DBS) / Whole Blood (WB) in EDTA Vacutainer
(The primary sample type for TMS-based newborn screening is Dried Blood Spot (DBS), typically collected via a heel prick on a filter paper card. Whole Blood (WB) in EDTA may sometimes be requested as a backup or for specific confirmatory tests depending on the lab's protocol, but the initial screening is performed on DBS.)
Preparation
Proper timing and sample collection are critical for the accuracy of TMS-based newborn screening. * Optimal Timing: The Dried Blood Spot (DBS) sample should ideally be collected between 24 to 72 hours... Read more
Schedule Report
7 Days
Emergency Report
Yes
Frequently Asked Questions
No data available
Test Description
- High-end laboratory & medical equipment.
- Outstanding doctor team.
- Personalized care & high-quality service.
- Tailormade health screening packages.