Molecular Genetic Somatic / Comprehensive Tumor 270 Gene Panel - NGS
Test Code
MOG40
Also Known As
No data available
Test Parameters Included
No data available
Department
MOLECULAR GENETICS
Methodology
NGS (Next-Generation Sequencing)
This advanced and extensive test utilizes Next-Generation Sequencing (NGS) to perform Comprehensive Genomic Profiling (CGP) of a tumor. NGS allows for the simultaneous analysis of DNA and/or RNA from a tumor sample to detect a wide array of somatic (acquired) genetic alterations across 270 genes. This panel goes beyond single-gene testing or smaller targeted panels, providing a holistic view of the tumor's molecular landscape. NGS enables the detection of:
* Single Nucleotide Variants (SNVs): Changes in a single DNA base pair (e.g., KRAS G12C, EGFR L858R).
* Insertions and Deletions (Indels): Small additions or removals of DNA bases.
* Copy Number Variations (CNVs): Amplifications (too many copies) or deletions (too few copies) of specific genes (e.g., HER2 amplification).
* Gene Fusions/Rearrangements: When two normally separate genes break and rejoin, creating a new, often oncogenic, fusion gene (e.g., ALK, ROS1, RET, NTRK fusions).
* Tumor Mutational Burden (TMB): A measure of the total number of mutations within the tumor's genome, which can predict response to immunotherapy.
* Microsatellite Instability (MSI): Changes in repetitive DNA sequences due to mismatch repair deficiency, also a predictor for immunotherapy response.
The high-throughput and sensitive nature of NGS are critical for analyzing the complex and often heterogeneous genetic makeup of tumors, even from limited biopsy samples.
Sample Required
FFPE TISSUE > 10% CANCER
(Formalin-Fixed Paraffin-Embedded (FFPE) tumor tissue is the required sample type. It is crucial that the tissue block or scrolls submitted contain greater than 10% cancer cells to ensure sufficient tumor DNA/RNA for accurate analysis. Ideally, a matched normal sample (e.g., peripheral blood in EDTA) may be requested by some labs for comparison, though advanced bioinformatics can often filter out common germline variants without it.)
Preparation
Preparation for this test primarily involves proper collection and handling of the tumor tissue. * Sample Type: Formalin-Fixed Paraffin-Embedded (FFPE) tumor tissue block or scrolls. This is the stand... Read more
Schedule Report
35 Days
Emergency Report
Yes
Frequently Asked Questions
No data available
Test Description
- High-end laboratory & medical equipment.
- Outstanding doctor team.
- Personalized care & high-quality service.
- Tailormade health screening packages.