Molecular Genetic IKZF1 Alterations - MLPA
Test Code
MOG24
Also Known As
No data available
Test Parameters Included
No data available
Department
MOLECULAR GENETICS
Methodology
MLPA (Multiplex Ligation-dependent Probe Amplification)
MLPA (Multiplex Ligation-dependent Probe Amplification) is the specialized molecular technique used for detecting IKZF1 alterations. The IKZF1 gene encodes for Ikaros, a crucial transcription factor involved in lymphoid development and tumor suppression. Deletions, which are a common type of alteration in IKZF1, lead to haploinsufficiency or the production of dominant-negative isoforms. MLPA is an ideal method for detecting these copy number variations (CNVs), specifically deletions and duplications of entire exons or even the whole gene. MLPA uses multiple probes that bind to specific sequences within the IKZF1 gene. By quantifying the relative amount of each targeted DNA sequence, MLPA can precisely identify gains or losses in copy number. This method is highly sensitive and specific for detecting IKZF1 deletions, which are key prognostic markers in various hematologic malignancies, particularly B-cell acute lymphoblastic leukemia (B-ALL).
Sample Required
WB/BMA EDTA: Whole Blood (WB) or Bone Marrow Aspirate (BMA) in EDTA Vacutainer
(A sample of whole blood or bone marrow aspirate collected in an EDTA vacutainer is required for this test. EDTA acts as an anticoagulant to preserve the sample for DNA extraction.)
Preparation
No specific preparation is typically required for this genetic test. * No Fasting Required: Fasting is not necessary for this blood or bone marrow sample collection. * No Special Timing: Sample can be... Read more
Schedule Report
15 Days
Emergency Report
Yes
Frequently Asked Questions
No data available
Test Description
- High-end laboratory & medical equipment.
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